CBD and Anxiety
Anxiety is a normal coping mechanism; however, in excess, it can be detrimental. More than just a situational response, anxiety disorders are characterized by a persistent and oftentimes irrational dread of everyday situations which can interfere with daily activities.
Prevalence of Anxiety in the USA
Forty million U.S. adults are affected by an anxiety-related disorder; however, the prevalence of these disorders should not diminish their impact.
Excessive anxiety is a central symptom of several neuropsychiatric disorders. These include generalized anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD). Anxiety is a complex disorder that can develop through various factors including genetics, brain chemistry, personality, and life events.
About Anxiety and Emotional Response
Anxiety is our bodies’ response to an emotional situation. Biologically, anxiety activates our “fight or flight” response to warn us of potential threats.
During such time, norepinephrine and cortisol flood our system to boost perception, reflexes, and speed. These chemicals increase the heart rate, blood flow to the muscles, and air flow. With chronic anxiety, the response is never deactivated, and the physical and emotional effects of anxiety remain.
Anxiety and the Endocannabinoid System (ECS)
The endocannabinoid system (ECS) plays an integral role in regulating emotional response. Specifically, the ECS supports nerve activity that determines our response to emotional or aversive events.
The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871913/
An Introduction to the ECS
The endocannabinoid system is a biological system responsible for maintaining homeostasis. The ECS is composed of endocannabinoids, degradative enzymes, and cannabinoid receptors. Endocannabinoids such as anandamide (“the bliss molecule”) and 2-arachidonoylglycerol (2AG) are synthesized, or created, by our bodies on demand, in response to an imbalance. They interact with the cannabinoid receptors to direct the body back to proper functioning.
CB1 Receptors and Anxiety
CB1 receptors, which are primarily located on nerve endings, are one of the two major cannabinoid receptors. According to studies, the activation of the CB1 receptors produces anxiolytic (anti-anxiety) effects.
When one considers conditioned fear, the effect of CB1 receptor activation is complex. However, CB1 receptor activation can reduce fear and prevent the activation of existing memories from the past. Additionally, CB1 receptor activation protects against the adverse effects of chronic stress, which can lead to anxiety. For this reason, CB1 receptor activation has been studied for anxiolytic drug development.
Endocannabinoids activate the CB1 receptor; therefore, a higher level of endocannabinoids can be beneficial for those with anxiety-related disorders. Additionally, chemicals that inhibit the FAAH enzyme from breaking down anandamide increase endocannabinoid availability and are also being studied for their anxiolytic effects.
Living with Anxiety
There are many ways to manage anxiety; however, less than 40% of those with an anxiety disorder seek treatment. Still today there is a stigma surrounding mental illness that discourages those struggling from seeking help. We can help end the stigma of mental illness by having open conversations about mental health, encouraging mental health education, and showing compassion to those with a mental illness.
If you or a loved one is struggling with an anxiety disorder, we encourage you to learn more about the disorder and the options for treatment.
I’ve struggled with anxiety for over 9 years… after my first session it was like the cloud and tension had vanished!Testimonial
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